Looking at the Week 6 NFL slate, we have the Eagles (-8.5) as the best bet on the card. Scroll down for more tips on point spreads and over/unders, including parlay possibilities.

Take advantage of our predictions to make your NFL picks this week. BetMGM has all the information you need to begin betting on the NFL.

Best Week 6 Spread Bets

Jump to Matchup:

IND-TEN | JAX-CHI | BUF-NYJ | PIT-LV | LAC-DEN

Pick: Titans +1 vs. Colts

• Matchup: Indianapolis Colts at Tennessee Titans
• Projected Winner & Margin: Colts by 0.6 points (Bet on this game at BetMGM)
• Spread: Colts -1
• Time: 1:00 p.m. ET
• Date: Oct. 13
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Bears -2.5 vs. Jaguars

• Matchup: Jacksonville Jaguars vs. Chicago Bears
• Projected Winner & Margin: Bears by 13.5 points (Bet on this game at BetMGM)
• Spread: Bears -2.5
• Time: 9:30 a.m. ET
• Date: Oct. 13
• TV Channel: NFL Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Jets +2.5 vs. Bills

• Matchup: Buffalo Bills at New York Jets
• Projected Winner & Margin: Jets by 3.2 points (Bet on this game at BetMGM)
• Spread: Bills -2.5
• Time: 8:15 p.m. ET
• Date: Oct. 14
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Steelers -3 vs. Raiders

• Matchup: Pittsburgh Steelers at Las Vegas Raiders
• Projected Winner & Margin: Steelers by 8.7 points (Bet on this game at BetMGM)
• Spread: Steelers -3
• Time: 4:05 p.m. ET
• Date: Oct. 13
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Broncos +3 vs. Chargers

• Matchup: Los Angeles Chargers at Denver Broncos
• Projected Winner & Margin: Broncos by 6.4 points (Bet on this game at BetMGM)
• Spread: Chargers -3
• Time: 4:05 p.m. ET
• Date: Oct. 13
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Make smart decisions. Use those stats when making your NFL picks and place your bet on BetMGM.

Best Week 6 Total Bets

Jump to Matchup:

Over 41.5 – Buccaneers vs. Saints

• Matchup: Tampa Bay Buccaneers at New Orleans Saints
• Projected Total: 47.7 points (Bet on this game at BetMGM)
• Time: 1:00 p.m. ET
• Date: Oct. 13
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 52.5 – Commanders vs. Ravens

• Matchup: Washington Commanders at Baltimore Ravens
• Projected Total: 54.3 points (Bet on this game at BetMGM)
• Time: 1:00 p.m. ET
• Date: Oct. 13
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Under 35.5 – Chargers vs. Broncos

• Matchup: Los Angeles Chargers at Denver Broncos
• Projected Total: 31.7 points (Bet on this game at BetMGM)
• Time: 4:05 p.m. ET
• Date: Oct. 13
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Under 49.5 – Cardinals vs. Packers

• Matchup: Arizona Cardinals at Green Bay Packers
• Projected Total: 48.5 points (Bet on this game at BetMGM)
• Time: 1:00 p.m. ET
• Date: Oct. 13
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 52.5 – Lions vs. Cowboys

• Matchup: Detroit Lions at Dallas Cowboys
• Projected Total: 47.1 points (Bet on this game at BetMGM)
• Time: 4:25 p.m. ET
• Date: Oct. 13
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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