On the Week 5 NFL schedule, we have the Texans (+1) as the best against-the-spread bet on the card. Scroll down for more suggestions on point spreads and over/unders, including parlay possibilities.

NFL Picks Against the Spread – Week 5

Jump to Matchup:

Pick: Texans +1 vs. Bills

• Matchup: Buffalo Bills at Houston Texans
• Projected Winner & Margin: Texans by 2.1 points (Bet on this game at BetMGM)
• Spread: Bills -1
• Time: 1:00 p.m. ET
• Date: Oct. 6
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Patriots -1 vs. Dolphins

• Matchup: Miami Dolphins at New England Patriots
• Projected Winner & Margin: Patriots by 4.0 points (Bet on this game at BetMGM)
• Spread: Patriots -1
• Time: 1:00 p.m. ET
• Date: Oct. 6
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Buccaneers +1.5 vs. Falcons

• Matchup: Tampa Bay Buccaneers at Atlanta Falcons
• Projected Winner & Margin: Falcons by 0.7 points (Bet on this game at BetMGM)
• Spread: Falcons -1.5
• Time: 8:15 p.m. ET
• Date: Oct. 3
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Vikings -2.5 vs. Jets

• Matchup: New York Jets vs. Minnesota Vikings
• Projected Winner & Margin: Vikings by 5.2 points (Bet on this game at BetMGM)
• Spread: Vikings -2.5
• Time: 9:30 a.m. ET
• Date: Oct. 6
• TV Channel: NFL Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Bengals +2.5 vs. Ravens

• Matchup: Baltimore Ravens at Cincinnati Bengals
• Projected Winner & Margin: Ravens by 1.2 points (Bet on this game at BetMGM)
• Spread: Ravens -2.5
• Time: 1:00 p.m. ET
• Date: Oct. 6
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Steelers -2.5 vs. Cowboys

• Matchup: Dallas Cowboys at Pittsburgh Steelers
• Projected Winner & Margin: Steelers by 6.0 points (Bet on this game at BetMGM)
• Spread: Steelers -2.5
• Time: 8:20 p.m. ET
• Date: Oct. 6
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Colts +3 vs. Jaguars

• Matchup: Indianapolis Colts at Jacksonville Jaguars
• Projected Winner & Margin: Colts by 3.2 points (Bet on this game at BetMGM)
• Spread: Jaguars -3
• Time: 1:00 p.m. ET
• Date: Oct. 6
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Broncos -3 vs. Raiders

• Matchup: Las Vegas Raiders at Denver Broncos
• Projected Winner & Margin: Broncos by 6.8 points (Bet on this game at BetMGM)
• Spread: Broncos -3
• Time: 4:05 p.m. ET
• Date: Oct. 6
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Bears -3.5 vs. Panthers

• Matchup: Carolina Panthers at Chicago Bears
• Projected Winner & Margin: Bears by 7.9 points (Bet on this game at BetMGM)
• Spread: Bears -3.5
• Time: 1:00 p.m. ET
• Date: Oct. 6
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Commanders -3.5 vs. Browns

• Matchup: Cleveland Browns at Washington Commanders
• Projected Winner & Margin: Commanders by 4.4 points (Bet on this game at BetMGM)
• Spread: Commanders -3.5
• Time: 1:00 p.m. ET
• Date: Oct. 6
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Rams +3.5 vs. Packers

• Matchup: Green Bay Packers at Los Angeles Rams
• Projected Winner & Margin: Rams by 0.5 points (Bet on this game at BetMGM)
• Spread: Packers -3.5
• Time: 4:25 p.m. ET
• Date: Oct. 6
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Saints +5 vs. Chiefs

• Matchup: New Orleans Saints at Kansas City Chiefs
• Projected Winner & Margin: Chiefs by 4.6 points (Bet on this game at BetMGM)
• Spread: Chiefs -5
• Time: 8:15 p.m. ET
• Date: Oct. 7
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Seahawks -6 vs. Giants

• Matchup: New York Giants at Seattle Seahawks
• Projected Winner & Margin: Seahawks by 7.0 points (Bet on this game at BetMGM)
• Spread: Seahawks -6
• Time: 4:25 p.m. ET
• Date: Oct. 6
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: 49ers -7.5 vs. Cardinals

• Matchup: Arizona Cardinals at San Francisco 49ers
• Projected Winner & Margin: 49ers by 10.3 points (Bet on this game at BetMGM)
• Spread: 49ers -7.5
• Time: 4:05 p.m. ET
• Date: Oct. 6
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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